RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A-YTHDF2-dependent manner.

Dingcheng ShenJinxin LinYumo XieZhuokai ZhuangGaopo XuShaoyong PengGuannan TangLiangliang BaiMingxuan ZhuYu ZhangZiying HuangPuning WangXiaoxia LiuMeijin HuangYanxin LuoXiaolin WangHuichuan Yu

Published in: Clinical and translational medicine (2023)

ALKBH5 facilitates the progression of CRC by augmenting the expression of RAB5A via an m6A-YTHDF2-dependent manner. Our findings suggested that ALKBH5-RAB5A axis might serve as valuable biomarkers and effective therapeutic targets for CRC.

Keyphrases

poor prognosis
binding protein