Si-Ni-San Reduces Hepatic Lipid Deposition in Rats with Metabolic Associated Fatty Liver Disease by AMPK/SIRT1 Pathway.

Ning ZhangTong LiuJianan WangYingying XiaoYing ZhangJun DaiZhi Hong Ma Donglai Ma

Published in: Drug design, development and therapy (2023)

SNS could reduce hepatic lipid deposition by inhibiting lipid synthesis and promoting fatty acid oxidation, which might be related with activating the AMPK/SIRT1 signaling pathway. This study could provide a theoretical basis for the clinical use of SNS to treat MAFLD.

Keyphrases

fatty acid
signaling pathway
skeletal muscle
pi k akt
ischemia reperfusion injury
epithelial mesenchymal transition
protein kinase
induced apoptosis
nitric oxide
room temperature