Multimaterial decomposition in dual-energy CT for characterization of clots from acute ischemic stroke patients.
Melina GassenhuberMaximilian E LochschmidtJohannes HammelTobias Boeckh-BehrensBenno IkenbergSilke WunderlichFriederike Liesche-StarneckerJürgen SchlegelFranz PfeifferMarcus R MakowskiClaus ZimmerIsabelle RiedererDaniela PfeifferPublished in: European radiology experimental (2024)
• Acute ischemic stroke clots present different recanalization success according to histological composition. • Currently, no method can determine clot composition prior to intervention. • DE-CT allows quantitative material decomposition of thrombi ex vivo in red blood cells, white blood cells, and fibrin/platelets. • Histological clot composition differs between stroke etiology. • Insights into the histological composition in situ offer personalized treatment strategies.
Keyphrases
- dual energy
- computed tomography
- acute ischemic stroke
- image quality
- red blood cell
- contrast enhanced
- randomized controlled trial
- induced apoptosis
- magnetic resonance imaging
- atrial fibrillation
- positron emission tomography
- high resolution
- intensive care unit
- oxidative stress
- cerebral ischemia
- drug induced
- endoplasmic reticulum stress