Treponema pallidum protein Tp47 induced prostaglandin E2 to inhibit the phagocytosis in human macrophages.

D-Y YiQ-Y XuY HeX-Q ZhengTian-Ci Yang Y Lin

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2024)

Tp47-induced PGE2 production via the PERK/NF-κB/COX-2 pathway contributed to macrophage phagocytosis inhibition, which potentially contributes to immune evasion during the T. pallidum infection.

Keyphrases

high glucose
endothelial cells
diabetic rats
adipose tissue
endoplasmic reticulum stress
pi k akt
binding protein
small molecule
cell proliferation
pluripotent stem cells
toll like receptor