Managing intrathecal administration of nusinersen in adolescents and adults with 5q-spinal muscular atrophy and previous spinal surgery.
Rodrigo de Holanda MendonçaHermann Dos Santos FernandesRafael Barbéro Schimmelpfeng PintoCiro MatsuiGraziela Jorge PolidoAndré Macedo Serafim da SilvaLuis Fernando GrossklaussUmbertina Conti ReedEdmar ZanoteliPublished in: Arquivos de neuro-psiquiatria (2021)
In SMA patients with previous spinal surgery, the use of imaging-guided intervention is necessary for administering intrathecal nusinersen. Transforaminal technique is indicated in patients for whom the interlaminar space is not available, and injections should always be guided by either CT or fluoroscopy.
Keyphrases
- minimally invasive
- coronary artery bypass
- spinal cord
- end stage renal disease
- randomized controlled trial
- ejection fraction
- newly diagnosed
- young adults
- computed tomography
- high resolution
- prognostic factors
- magnetic resonance imaging
- image quality
- patient reported outcomes
- magnetic resonance
- photodynamic therapy
- contrast enhanced
- ultrasound guided
- positron emission tomography
- platelet rich plasma
- fluorescence imaging