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Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis-findings from the EU-GEI study.

Luis AlamedaZhonghua LiuPak C ShamMonica AasGiulia TrottaVictoria RodriguezMarta Di FortiSimona A StiloRadhika KandaswamyCelso ArangoManuel ArrojoMiguel BernardoJulio BobesLieuwe de HaanCristina Marta Del BenCharlotte Gayer-AndersonLucia SideliPeter B JonesHannah E JongsmaJames Bowes KirkbrideCaterina La CasciaAntonio LasalviaSarah TosatoPierre Michel LlorcaPaulo Rossi MenezesJim Van OsDiego QuattroneBart P F RuttenJose Luis SantosJulio SanjuánJean-Paul SeltenAndrei SzökeIlaria TarriconeAndrea TortelliEva VelthorstCraig MorganEmma L DempsterEilis J HannonJoe BurrageDaniella DwirAtheeshaan ArumuhamJonathan S MillRobin M MurrayChloe C Y Wong
Published in: Molecular psychiatry (2023)
) for composite, abuse and neglect respectively, with a lack of overlap between abuse and neglect. These included genes previously associated to psychosis in EWAS studies, such as PANK1, SPEG TBKBP1, TSNARE1 or H2R. Downstream gene ontology analyses did not reveal any biological pathways that survived false discovery rate correction. Although at a non-significant level, DNAm changes in genes previously associated with schizophrenia in EWAS studies may mediate the CA-psychosis association. These results and associated involved processes such as mitochondrial or histaminergic disfunction, immunity or neural signalling requires replication in well powered samples. The lack of overlap between mediating genes associated with abuse and neglect suggests differential biological trajectories linking CA subtypes and psychosis.
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