Norepinephrine may promote the progression of Fusobacterium nucleatum related colorectal cancer via quorum sensing signalling.
Xinhao DuZhenzhen TangLi YanLing ZhangQiao ZhengXianghao ZengQing HuQian TianLanfan LiangXinyu ZhaoJun LiMing ZhaoXiangsheng FuPublished in: Virulence (2024)
Fusobacterium nucleatum (F. nucleatum) is closely correlated with tumorigenesis in colorectal cancer (CRC). We aimed to investigate the effects of host norepinephrine on the carcinogenicity of F. nucleatum in CRC and reveal the underlying mechanism. The results revealed that both norepinephrine and bacterial quorum sensing (QS) molecule auto-inducer-2 (AI-2) were positively associated with the progression of F. nucleatum related CRC ( p < 0.01). In vitro studies, norepinephrine induced upregulation of QS-associated genes and promoted the virulence and proliferation of F. nucleatum . Moreover, chronic stress significantly increased the colon tumour burden of Apc Min/+ mice infected with F. nucleatum ( p < 0.01), which was decreased by a catecholamine inhibitor ( p < 0.001). Our findings suggest that stress-induced norepinephrine may promote the progression of F. nucleatum related CRC via bacterial QS signalling. These preliminary data provide a novel strategy for the management of pathogenic bacteria by targeting host hormones-bacterial QS inter-kingdom signalling.
Keyphrases
- stress induced
- signaling pathway
- escherichia coli
- genome wide
- drug induced
- cell proliferation
- pseudomonas aeruginosa
- machine learning
- type diabetes
- artificial intelligence
- dna methylation
- poor prognosis
- oxidative stress
- deep learning
- big data
- cystic fibrosis
- endothelial cells
- high glucose
- long non coding rna
- antimicrobial resistance