In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review.

Robert H Guirguis Leonard P TanRebecca M HicksAniqa HasanTina D DuongXia HuJordan Y S HngMohammad H HadiHenry C OwuamaTamara MatthyssenMichael J McCullough Federica Canfora Rita Paolini Antonio Celentano

Published in: Biomolecules (2023)

Antiresorptive and antiangiogenic drugs displayed cytotoxic effects in a dose and time-dependent manner. Additional research is required to further elucidate the pathways of MRONJ.

Keyphrases

systematic review
meta analyses
gene expression
randomized controlled trial