KEOPS complex expression in the frontal cortex in major depression and schizophrenia.

Mackenzie E AbelXiaolu ZhangSophie M AsahAlyssa WolfingerRobert E McCullumsmithSinead Marie O'Donovan

Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2020)

This study is the first to describe KEOPS complex expression in post-mortem brain and neuropsychiatric disorders. KEOPS subunit mRNA expression is not significantly altered in the DLPFC in MDD or schizophrenia. Unlike in yeast, the KEOPS complex does not appear to play a role in telomere length regulation in humans or in neuropsychiatric disorders.

Keyphrases

poor prognosis
bipolar disorder
functional connectivity
resting state
major depressive disorder
binding protein
white matter
multiple sclerosis
working memory
brain injury
cell wall