NPC-0501 trial on the value of changing chemoradiotherapy sequence, replacing 5-fluorouracil with capecitabine, and altering fractionation for patients with advanced nasopharyngeal carcinoma.
Anne Wing-Mui LeeRoger K C NganWai-Tong NgStewart Y TungAshley A C ChengDora L W KwongTai-Xiang LuAnthony T C ChanHenry C K SzeHarry H Y YiuFrank C S WongKam-Tong YuenRick ChappellHorace C W ChoiPublished in: Cancer (2020)
For patients irradiated using conventional fractionation, changing the chemotherapy sequence from a concurrent-adjuvant to an induction-concurrent sequence, particularly using induction cisplatin and capecitabine, potentially could improve efficacy without an adverse impact on late toxicity. However, further validation is needed for confirmation of these findings.
Keyphrases
- locally advanced
- rectal cancer
- squamous cell carcinoma
- phase ii study
- end stage renal disease
- phase iii
- radiation therapy
- ejection fraction
- chronic kidney disease
- newly diagnosed
- clinical trial
- oxidative stress
- peritoneal dialysis
- prognostic factors
- amino acid
- metastatic breast cancer
- randomized controlled trial
- patient reported outcomes
- metastatic colorectal cancer
- patient reported
- placebo controlled