Selective Imaging of Lipids in Adipocytes by Using an Imidazolyl Derivative of Perylene Bisimide.
Ruchika MishraZeeshan MushtaqRamprasad RegarBhagaban MallikVimlesh KumarJeyaraman SankarPublished in: Chembiochem : a European journal of chemical biology (2018)
A small molecule, perylene bisimide imidazolyl derivative (PBI-ID), has been identified and developed as a specific marker for labelling multifunctional fat bodies in various organisms, including Drosophila and mammalian adipocytes. Interestingly, PBI-ID neither labels the plasma membranes nor cell nuclei by trapping into it. A remarkable feature of unbound PBI-ID is diminished fluorescence, which reduces the background emission noise, while contrasting the bound state effectively.
Keyphrases
- adipose tissue
- small molecule
- perovskite solar cells
- high resolution
- single cell
- drug delivery
- machine learning
- fatty acid
- cell therapy
- air pollution
- protein protein
- water soluble
- deep learning
- insulin resistance
- high fat diet induced
- single molecule
- type diabetes
- gram negative
- multidrug resistant
- skeletal muscle
- bone marrow
- metal organic framework
- photodynamic therapy