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Expression of miR-15a, miR-145, and miR-182 in granulosa-lutein cells, follicular fluid, and serum of women with polycystic ovary syndrome (PCOS).

Mohammad NajiSaeid NekoonamAshraf AleyasinEhsan ArefianReza MahdianElham AziziMaryam Shabani NashtaeiFardin Amidi
Published in: Archives of gynecology and obstetrics (2017)
A significant dysregulation of miR-145 and miR-182 in GLCs of PCOS may indicate their involvement in pathogenesis of PCOS. Differential up-regulation of miR-182 in FF of PCOS patients with its promising predictive values for discrimination of PCOS reinforced the importance of studying miRNAs' profile in FF.
Keyphrases
  • polycystic ovary syndrome
  • cell proliferation
  • long non coding rna
  • long noncoding rna
  • poor prognosis
  • insulin resistance
  • type diabetes
  • skeletal muscle