Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial.
Miguel Ruiz-CanelaMarta Guasch-FerréEstefanía ToledoClary B ClishCristina RazquinLiming LiangDong D WangDolores CorellaRamón EstruchÁlvaro HernáezEdward YuEnrique Gómez-GraciaYan ZhengFernando ArósDora RomagueraCourtney DennisEmilio RosJosé LapetraLluis Serra-MajemChristopher PapandreouOlga PortolesMontserrat FitóJordi Salas-SalvadóFrank B HuMiguel A Martínez-GonzálezPublished in: Diabetologia (2018)
Our results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence. Clinical trial number: SRCTN35739639 ( www.controlled-trials.com ).