Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.
Brenna C NovotnyMaria Victoria FernandezCiyang WangJohn P BuddeKristy BergmannAbdallah M EteleebJoseph BradleyCarol WebsterCurtis EblJoanne NortonJen GentschUmber DubeFengxian WangJohn C MorrisRandell J BatemanRichard J PerrinEric McDadeChengjie XiongJasmeer P Chhatwalnull nullnull nullnull nullAlison Mary GoateMartin FarlowPeter R SchofieldHelena ChuiCeleste M KarchCruchaga CarlosBruno A BenitezOscar HarariPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)
APP/PSEN1/PSEN2 and TREM2 variant carriers show distinct metabolic changes. A total of 133 metabolites were differentially abundant in AD genetic groups. β-citrylglutamate is differentially abundant in autosomal dominant, TREM2, and sporadic AD. A 16-metabolite profile shows differences between Alzheimer's disease (AD) genetic groups. The identified metabolic profile is associated with duration of disease.