An Electrochemical Route for Special Oxidative Ring-Opening of Indoles.
Hong QinZhao YangZhen ZhangChengkou LiuWei HeZheng FangKai GuoPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2021)
A novel electrochemical protocol for the oxidative cleavage of indoles has been developed, which offers a simple way to access synthetically useful anthranilic acid derivatives. In undivided cells, a wide variety of indoles and alcohol compounds are examined to afford amide ester aromatics without using extra oxidants and stoichiometric metal catalysts, which avoids the formation of undesired by-products and exhibits high atom economy. The products we described in this perspective represent a synthetic intermediate in numerous drug molecules and industrial chemical reagents and remarkably show potential application in the future.
Keyphrases
- gold nanoparticles
- induced apoptosis
- ionic liquid
- molecularly imprinted
- cell cycle arrest
- label free
- randomized controlled trial
- electron transfer
- heavy metals
- wastewater treatment
- current status
- molecular dynamics
- endoplasmic reticulum stress
- dna binding
- emergency department
- cell death
- signaling pathway
- alcohol consumption
- risk assessment
- climate change
- transcription factor