KYNA analogue SZR72 modifies CFA-induced dural inflammation- regarding expression of pERK1/2 and IL-1β in the rat trigeminal ganglion.

M LukácsKarin WarfvingeL S KruseJ TajtiF FülöpJ ToldiL VécseiL Edvinsson

Published in: The journal of headache and pain (2016)

This is the first study that demonstrates that one dose of KYNA analog before application of CFA can give anti-inflammatory response in a model of trigeminal activation, opening a new line for further investigations regarding possible effects of KYNA derivates.

Keyphrases

inflammatory response
neuropathic pain
oxidative stress
poor prognosis
diabetic rats
high glucose
lipopolysaccharide induced
spinal cord injury
endoplasmic reticulum stress
lps induced
binding protein
immune response
toll like receptor
long non coding rna