Adjuvant EGFR tyrosine kinase inhibitors for patients with resected EGFR -mutated non-small-cell lung cancer: a network meta-analysis.
Wentao TianNuopei TanJiawen KeJi'an ZouXiaohan LiuYue PanYue ZengYurong PengFang WuPublished in: Future oncology (London, England) (2022)
Aim: To investigate the efficacy and safety of adjuvant EGFR tyrosine kinase inhibitors for resected EGFR -mutated non-small-cell lung cancer. Materials & methods: Eligible phase II/III randomized controlled trials were included for the network meta-analyses (PROSPERO CRD42021275150). Results: Nine records and 831 patients were involved. Adjuvant chemotherapy followed with osimertinib significantly prolonged disease-free survival compared with chemotherapy (hazard ratio [HR]: 0.2; 95% CI: 0.14-0.29), chemotherapy followed with erlotinib (HR: 0.33; 95% CI: 0.18-0.6), chemotherapy followed with gefitinib (HR: 0.36; 95% CI: 0.16-0.82), gefitinib (HR: 0.26; 95% CI: 0.17-0.41) and icotinib (HR: 0.56; 95% CI: 0.3-0.98). Icotinib was the least likely to cause grade ≥3 adverse events. Conclusion: Chemotherapy followed with osimertinib brings about the best disease-free survival. Icotinib monotherapy shows the best safety.
Keyphrases
- epidermal growth factor receptor
- small cell lung cancer
- free survival
- tyrosine kinase
- advanced non small cell lung cancer
- locally advanced
- phase ii
- meta analyses
- end stage renal disease
- randomized controlled trial
- prognostic factors
- early stage
- systematic review
- open label
- chronic kidney disease
- lymph node
- newly diagnosed
- squamous cell carcinoma
- chemotherapy induced
- peritoneal dialysis
- combination therapy
- phase iii
- double blind