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NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome.

Tatsuaki KurosakiHitomi SakanoChristoph PröschelJason WheelerAlexander HewkoLynne E Maquat
Published in: Genome biology (2021)
We reveal the abnormal regulation of these mRNAs in the Fmr1-KO mouse, a model of FXS, and highlight the importance of early intervention.
Keyphrases
  • mouse model
  • randomized controlled trial
  • white matter
  • resting state
  • genome wide
  • single cell
  • case report
  • cerebral ischemia
  • gene expression
  • blood brain barrier
  • wild type