Safety of direct-acting oral anticoagulant (DOAC) prescribing: OpenSAFELY-TPP analysis of 20.5 million adults' electronic health records.
Karen HomanRachel SeeleyLouis FisherSajida KhatriKatie SmithTony JamiesonVictoria SpeedCarol A RobertsAmir MehrkarSebastian BaconBrian MackennaBen GoldacrePublished in: BJGP open (2024)
CrCl is not recorded for a substantial number of patients on DOACs. We recommend that national organisations tasked with safety, collectively update guidance on the appropriate weight to use in the Cockcroft-Gault equation, clarify that CrCl is not equivalent to eGFR, and work with GP clinical system suppliers to standardise the calculation of CrCl in the EHR.
Keyphrases
- electronic health record
- end stage renal disease
- ejection fraction
- small cell lung cancer
- newly diagnosed
- primary care
- chronic kidney disease
- adverse drug
- clinical decision support
- atrial fibrillation
- physical activity
- prognostic factors
- epidermal growth factor receptor
- tyrosine kinase
- quality improvement
- emergency department
- patient reported outcomes
- weight gain