Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring.
Josca Mariëtte SchoonejansHeather L BlackmoreThomas J AshmoreLucas Carminatti PantaleãoLuciana Pellegrini PisaniLaura DeardenJohn A TadrossCatherine E AikenDenise S Fernandez-TwinnSusan E OzannePublished in: Diabetologia (2022)
Maternal metformin treatment of obese dams increased offspring metabolic risk factors in a sex- and age-dependent manner. These observations highlight the importance of following up offspring of both sexes beyond early adulthood after interventions during pregnancy. Our findings illustrate the complexity of balancing short-term benefits to mother and child vs any potential long-term metabolic effects on the offspring when prescribing therapeutic agents that cross the placenta.
Keyphrases
- body composition
- high fat diet
- adipose tissue
- risk factors
- pregnancy outcomes
- weight loss
- mental health
- metabolic syndrome
- type diabetes
- public health
- resistance training
- primary care
- randomized controlled trial
- healthcare
- birth weight
- bone mineral density
- insulin resistance
- physical activity
- obese patients
- blood pressure
- bariatric surgery
- body mass index
- climate change
- combination therapy
- postmenopausal women
- social media
- adverse drug