Organoarsenic probes to study proteins by NMR spectroscopy.

Mithun C MahawaththaHenry W OrtonIbidolapo AdekoyaThomas HuberGottfried Otting Christoph Nitsche

Published in: Chemical communications (Cambridge, England) (2022)

Arsenical probes enable structural studies of proteins. We report the first organoarsenic probes for nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy to study proteins in solutions. These probes can be attached to irregular loop regions. A lanthanide-binding tag induces sizable pseudocontact shifts in protein NMR spectra of a magnitude never observed for small paramagnetic probes before.

Keyphrases

magnetic resonance
single molecule
small molecule
living cells
fluorescence imaging
high resolution
magnetic resonance imaging
computed tomography
contrast enhanced
solar cells