Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity.
Diana Le DucChen-Ching LinYulia PopkovaZuqin YangVelluva AkhilMehmet Volkan ÇakirSonja GrunewaldJan-Christoph SimonAndreas DietzDirk DannenbergerJudith LorenzJohannes R LemkeJürgen SchillerMatthias BlüherPamela Arielle Nono NankamUlrike E Rolle-KampczykMartin von BergenJanet KelsoTorsten SchönebergPublished in: International journal of obesity (2005) (2020)
We show that the common shared lipid accumulation mechanism in lipoma is a reduction in lipolysis, with most gene dysregulations leading to a reduced cAMP in the adipocyte. Superficial lipomas could thus be used as a model for lipid accumulation through altered lipolysis as found in obese patients.