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Effect of laminarin on the expression of GRP78 and GRP94 in rat after unilateral ureteral obstruction.

Cui ZhangJing GaoLan Zhang
Published in: Scandinavian journal of urology and nephrology (2012)
The results demonstrate that UUO activated the reaction of ERS and increased the expression of GRP78 and GRP94 in the early period after laminarin was applied, which helped the refolding, assembling and membrane transportation of denatured proteins. Consequently, the ERS signal transduction pathway was blocked, apoptosis was prevented and the development of renal interstitial fibrosis was reduced.
Keyphrases
  • endoplasmic reticulum stress
  • poor prognosis
  • cell surface
  • oxidative stress
  • binding protein
  • long non coding rna
  • cell death
  • cell cycle arrest
  • pi k akt