Oxidative stress and alterations in the expression of genes related to inflammation, DNA damage, and metal exposure in lung cells exposed to a hydroethanolic coal dust extract.
I P Tirado-BallestasN Alvarez-OrtegaW Maldonado-RojasJesús Olivero-VerbelKarina Caballero-GallardoPublished in: Molecular biology reports (2022)
In short, this study shows that despite hydroethanolic coal dust extract is not cytotoxic to Calu-1 cells, it produces an elevation of intracellular ROS and alters the expression in marker genes of oxidative stress, inflammation, metal transport, xenobiotic and lipid metabolism. These findings suggest that chemicals present in coal dust are biologically active and may interfere key biochemical process in the living organisms.
Keyphrases
- oxidative stress
- induced apoptosis
- dna damage
- diabetic rats
- heavy metals
- poor prognosis
- ischemia reperfusion injury
- health risk assessment
- health risk
- cell cycle arrest
- particulate matter
- cell death
- human health
- endoplasmic reticulum stress
- polycyclic aromatic hydrocarbons
- signaling pathway
- risk assessment
- gene expression
- long non coding rna
- transcription factor
- heat stress
- genome wide identification
- bioinformatics analysis
- genome wide analysis