Anti-Inflammatory Cembranoids from a Formosa Soft Coral Sarcophyton cherbonnieri.
Chia-Chi PengChiung-Yao HuangAtallah F AhmedTsong-Long HwangJyh-Horng SheuPublished in: Marine drugs (2020)
The present investigation on chemical constituents of the soft coral Sarcophyton cherbonnieri resulted in the isolation of seven new cembranoids, cherbonolides F-L (1-7). The chemical structures of 1-7 were determined by spectroscopic methods, including infrared, one- and two-dimensional (1D and 2D) NMR (COSY, HSQC, HMBC, and NOESY), MS experiments, and a chemical reduction of hydroperoxide by triphenylphosphine. The anti-inflammatory activities of 1-7 against neutrophil proinflammatory responses were evaluated by measuring their inhibitory ability toward N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced superoxide anion generation and elastase release in primary human neutrophils. The results showed that all isolates exhibited moderate activities, while cherbonolide G (2) and cherbonolide H (3) displayed a more active effect than others on the inhibition of elastase release (48.2% ± 6.2%) and superoxide anion generation (44.5% ± 4.6%) at 30 µM, respectively.
Keyphrases
- anti inflammatory
- endothelial cells
- high resolution
- ionic liquid
- high glucose
- hydrogen peroxide
- mass spectrometry
- magnetic resonance
- multiple sclerosis
- molecular docking
- diabetic rats
- ms ms
- induced pluripotent stem cells
- pluripotent stem cells
- high intensity
- drug induced
- solid state
- genetic diversity
- molecular dynamics simulations
- stress induced