Discovery of a proliferation essential gene signature and actin-like 6A as potential biomarkers for predicting prognosis and neoadjuvant chemotherapy response in triple-positive breast cancer.
Xiaofen LiShiping LuoWenfen FuMingyao HuangXiewei HuangShaohong KangJie ZhangQingshui WangChuan-Gui SongPublished in: Cancer (2024)
This efficient PEG signature prognostic model can predict the outcomes of TPBC. Furthermore, ACTL6A expression level was associated with the response to NACT, and could serve as an important factor in predicting prognosis and drug sensitivity of patients with TPBC.
Keyphrases
- neoadjuvant chemotherapy
- positive breast cancer
- locally advanced
- lymph node
- poor prognosis
- sentinel lymph node
- small molecule
- signaling pathway
- drug delivery
- copy number
- rectal cancer
- genome wide
- gene expression
- long non coding rna
- adipose tissue
- binding protein
- insulin resistance
- skeletal muscle
- single cell
- transcription factor
- glycemic control