Minocycline Enhance the Restorative Ability of Olfactory Ensheathing Cells by the Upregulation of BDNF and GDNF Expression After Spinal Cord Injury.

Soheila Pourkhodadad Shahrbanoo Oryan Mohammad Mehdi Hadipour Gholamreza Kaka Seyed Homayoon Sadraie

Published in: Basic and clinical neuroscience (2021)

This study examined the effect of combined treatment with minocycline and olfactory ensheathing cell on the BDNF and GDNF expression after spinal cord injury model in rat. The results showed that injection of minocycline before transplantation of OECs enhances expression of neurotrophic factors that lead to an appropriate environment for transplanted OECs and increases neuronal survival that promotes tissue sparing and functional recovery.

Keyphrases

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oxidative stress
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blood brain barrier
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replacement therapy