Prospective Phase II Open-Label Randomized Controlled Trial to Compare Mandibular Preservation in Upfront Surgery With Neoadjuvant Chemotherapy Followed by Surgery in Operable Oral Cavity Cancer.
Devendra ChaukarKumar PrabhashPawan RaneVijay Maruti PatilShivakumar ThiagarajanSarbani Ghosh LaskarShilpi SharmaPrathamesh S PaiPankaj ChaturvediSuhail SiddiquiAnuja DeshmukhDeepa NairSudhir Vasudevan NairRicha VaishVanita NoronhaAsawari PatilSupreeta AryaAnil K D'CruzPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
NACT plays a potential role in mandibular preservation in oral cancers with acceptable toxicities and no compromise in survival. However, this needs to be validated in a larger phase III randomized trial.
Keyphrases
- open label
- phase ii
- phase iii
- neoadjuvant chemotherapy
- clinical trial
- minimally invasive
- randomized controlled trial
- study protocol
- coronary artery bypass
- phase ii study
- locally advanced
- lymph node
- double blind
- placebo controlled
- sentinel lymph node
- surgical site infection
- papillary thyroid
- squamous cell carcinoma
- cone beam computed tomography
- early stage
- systematic review
- childhood cancer
- young adults
- percutaneous coronary intervention
- radiation therapy
- coronary artery disease
- free survival