Prion protein is associated with a worse prognosis of head and neck squamous cell carcinoma.
Eloa Mangabeira SantosCarlos Alberto DE Carvalho FragaAlessandra Rejane Ericsson de Oliveira XavierMauro Aparecido de Souza XavierMarcela Gonçalves SouzaSabrina Ferreira de JesusAlfredo Maurício Batista de PaulaLucyana Conceição FariasSérgio Henrique Sousa SantosTiago Goss SantosFlavio H BeraldoAndre Luiz Sena GuimaraesPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2021)
Our results collectively provide the first evidence that PRNP promotes HNSC lymph node metastasis progression through the upregulation of HSPA4, HSP90AA1 and HIF1A. Our findings may provide a molecular basis for the promoting Role of PRNP in HNSC progression.