The Key Role of Magnetic Resonance Imaging in the Detection of Neurodegenerative Diseases-Associated Biomarkers: A Review.
Ke-Ru LiAn-Guo WuYong TangXiao-Peng HeChong-Lin YuJian-Ming WuGuang-Qiang HuLu YuPublished in: Molecular neurobiology (2022)
Neurodegenerative diseases (NDs), including chronic disease such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis, and acute diseases like traumatic brain injury and ischemic stroke are characterized by progressive degeneration, brain tissue damage and loss of neurons, accompanied by behavioral and cognitive dysfunctions. So far, there are no complete cures for NDs; thus, early and timely diagnoses are essential and beneficial to patients' treatment. Magnetic resonance imaging (MRI) has become one of the advanced medical imaging techniques widely used in the clinical examination of NDs due to its non-invasive diagnostic value. In this review, research published in English in current decade from PubMed electronic database on the use of MRI to detect specific biomarkers of NDs was collected, summarized, and discussed, which provides valuable suggestions for the early diagnosis, prevention, and treatment of NDs in the clinic.
Keyphrases
- magnetic resonance imaging
- multiple sclerosis
- traumatic brain injury
- contrast enhanced
- end stage renal disease
- healthcare
- computed tomography
- oxidative stress
- newly diagnosed
- chronic kidney disease
- systematic review
- randomized controlled trial
- spinal cord
- atrial fibrillation
- prognostic factors
- resting state
- photodynamic therapy
- mass spectrometry
- intensive care unit
- combination therapy
- subarachnoid hemorrhage
- adverse drug
- patient reported
- cerebral ischemia
- mechanical ventilation
- label free
- meta analyses