RNA sequencing reveals BMP4 as a basis for the dual-target treatment of diabetic retinopathy.
Lijie DongZhe ZhangXun LiuQiong WangYaru HongXiaorong LiJuping LiuPublished in: Journal of molecular medicine (Berlin, Germany) (2020)
• High-glucose effect on vascular endothelial cell was analyzed by RNA-seq. • KEGG analysis revealed enrichment of TGF-beta signaling pathway. • SMAD9 and BMP4 expression was upregulated in all samples. • Dual-target therapy of PDR by antagonizing BMP4.
Keyphrases
- single cell
- rna seq
- high glucose
- diabetic retinopathy
- endothelial cells
- mesenchymal stem cells
- bone regeneration
- signaling pathway
- transforming growth factor
- epithelial mesenchymal transition
- optical coherence tomography
- poor prognosis
- stem cells
- replacement therapy
- vascular endothelial growth factor
- induced apoptosis
- bone marrow
- combination therapy
- long non coding rna