Childhood Adiposity and Risk of Major Clinical Heart Diseases in Adulthood: A Mendelian Randomization Study.
Yan XiongYijia TangJie ZhouYang TianFuli ChenGang LiHui HuangHao HuangLong ZhouPublished in: Journal of the American Heart Association (2024)
Our findings support the causal relationships between childhood adiposity and risk of adult coronary heart disease, myocardial infarction, heart failure, and atrial fibrillation. Blood lipids, hypertension, and type 2 diabetes are factors that mediate the aforementioned associations.
Keyphrases
- heart failure
- atrial fibrillation
- type diabetes
- insulin resistance
- early life
- childhood cancer
- left ventricular
- blood pressure
- weight gain
- depressive symptoms
- catheter ablation
- cardiovascular disease
- glycemic control
- oral anticoagulants
- left atrial appendage
- cardiac resynchronization therapy
- skeletal muscle
- direct oral anticoagulants
- fatty acid
- body mass index