ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection.
Clara BredowFabien TheryEva Katrin WirthSarah OchsMeike KespohlGunnar KleinauNicolas KelmNiclas GimberJan SchmoranzerMartin VossKarin KlingelJoachim SprangerKostja RenkoMarkus RalserMichael MüllederArnd HeuserKlaus-Peter KnobelochPatrick ScheererJennifer KirwanUlrike BrüningNikolaus BerndtFrancis ImpensAntje BelingPublished in: Cardiovascular research (2024)
Our study demonstrates that ISG15 controls critical nodes in cardiac metabolism. ISG15 reduces the glucose demand, supports higher ATP production capacity in the heart, despite nutrient shortage in infection, and counteracts cardiac atrophy and dysfunction.