Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice.
Fei ZengKarsten ParkerYanqiang ZhanMatthew MillerMeng-Yang ZhuPublished in: ASN neuro (2023)
The present study examined expression of DNA damage markers in VMAT2 Lo PD model mice. The results demonstrate there is a significant increase in these DNA damage markers mostly in the brain regions of 18- and 23-month-old model mice, indicating oxidative stress-induced DNA lesion is an important pathologic feature of this mouse model.
Keyphrases
- dna damage
- oxidative stress
- dna repair
- high fat diet induced
- mouse model
- machine learning
- poor prognosis
- neoadjuvant chemotherapy
- type diabetes
- single molecule
- wild type
- insulin resistance
- radiation therapy
- deep learning
- multiple sclerosis
- cell free
- adipose tissue
- brain injury
- functional connectivity
- circulating tumor cells
- cerebral ischemia
- rectal cancer