Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2.

Yujie YangLei LiuXiqian ZhangXuehua JiangLing Wang

Published in: Liver international : official journal of the International Association for the Study of the Liver (2019)

These results indicate that NRF2 regulates the target transporters BSEP and NTCP, depending on the DNA demethylation by TET2. Pharmacological activation of NRF2 by TAN IIA may be beneficial for RFP-induced liver injury.

Keyphrases

oxidative stress
poor prognosis
dna methylation
mycobacterium tuberculosis
gene expression
circulating tumor
single molecule
binding protein