Optimizing the design of invasive placebo interventions in randomized controlled trials.
Sian CousinsN S BlencoweC TsangK ChalmersA MardanpourA J CarrM K CampbellJonathan Alistair CookD J BeardJane M BlazebyPublished in: The British journal of surgery (2020)
DITTO considers invasive placebo composition systematically, accounting for risk, feasibility and placebo optimization. Use of the framework can support the design of high-quality RCTs, which are needed to underpin delivery of healthcare interventions.