Transcriptomic analysis of human norovirus NS1-2 protein highlights a multifunctional role in murine monocytes.
Zabeen LateefGregory GimenezEstelle S BakerVernon K WardPublished in: BMC genomics (2017)
RNAseq analysis showed that NS1-2 proteins from human and murine noroviruses affect multiple immune systems (chemokine, cytokine, and Toll-like receptor signaling) and intracellular pathways (NFκB, MAPK, PI3K-Akt signaling) in murine monocytes. Comparison to the transcriptomic profile of MNV-infected cells indicated the pathways that NS1-2 may affect during norovirus infection.
Keyphrases
- pi k akt
- signaling pathway
- toll like receptor
- cell cycle arrest
- induced apoptosis
- endothelial cells
- nuclear factor
- cell proliferation
- dengue virus
- inflammatory response
- oxidative stress
- induced pluripotent stem cells
- pluripotent stem cells
- immune response
- drug delivery
- dendritic cells
- peripheral blood
- single cell
- reactive oxygen species
- small molecule
- zika virus
- endoplasmic reticulum stress
- rna seq