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Decarboxylative Borylation of mCPBA-Activated Aliphatic Acids.

Dian WeiTu-Ming LiuBo ZhouBing Han
Published in: Organic letters (2019)
A decarboxylative borylation of aliphatic acids for the synthesis of a variety of alkylboronates has been developed by mixing m-chloroperoxybenzoic acid (mCPBA)-activated fatty acids with bis(catecholato)diboron in N,N-dimethylformamide (DMF) at room temperature. A radical chain process is involved in the reaction which initiates from the B-B bond homolysis followed by the radical transfer from the boron atom to the carbon atom with subsequent decarboxylation and borylation.
Keyphrases
  • room temperature
  • electron transfer
  • ionic liquid
  • fatty acid
  • molecular dynamics
  • visible light
  • transition metal