Impact of DNA Oxidation on Toxicology: From Quantification to Genomics.

Junzhou Wu Shana J Sturla Cynthia J Burrows Aaron M Fleming

Published in: Chemical research in toxicology (2019)

Understanding the toxicological implications of deoxyribonucleic acid (DNA) oxidation arising from cellular oxidative stress depends on identifying DNA oxidation products, their location in the genome, and their interaction with repair, replication, and gene expression.

Keyphrases

circulating tumor
gene expression
cell free
single molecule
oxidative stress
hydrogen peroxide
dna methylation
nucleic acid
single cell
electron transfer
circulating tumor cells
nitric oxide
genome wide
signaling pathway
induced apoptosis
diabetic rats