Expression differences of genes in the PI3K/AKT, WNT/b-catenin, SHH, NOTCH and MAPK signaling pathways in CD34+ hematopoietic cells obtained from chronic phase patients with chronic myeloid leukemia and from healthy controls.

R de Cássia Viu Carrara A M FontesK J AbrahamM D OrellanaS K HaddadP V B PalmaR A PanepucciM A ZagoD T Covas

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2017)

We show several mRNAs up- or downregulated in CD34-CML during the chronic phase.

Keyphrases

chronic myeloid leukemia
signaling pathway
induced apoptosis
cell proliferation
pi k akt
cell cycle arrest
epithelial mesenchymal transition
poor prognosis
stem cells
oxidative stress
bone marrow
genome wide
nk cells
endoplasmic reticulum stress
gene expression
dna methylation
binding protein
drug induced
cell death