Giant Cell Urothelial Carcinoma of Bladder.
Harshima Disvini WijesingheAjith Peiris MalalasekeraPublished in: Case reports in urology (2021)
Giant cell urothelial carcinoma is a rare variant of bladder cancer recognized by the current World Health Organization classification of urologic tumours. It is an aggressive tumour with a poor prognosis that usually presents at an advanced stage. It is characterized histologically by pleomorphic giant cells. We discuss a case of giant cell urothelial carcinoma presenting at an early stage in a previously well 62-year-old woman. Histology showed a tumour comprising pancytokeratin positive bizarre mononuclear and multi-nuclear giant cells admixed with areas of conventional urothelial carcinoma and carcinoma in situ. Three-month follow-up cystoscopy and magnetic resonance imaging showed no evidence of recurrence or pelvic lymphadenopathy.
Keyphrases
- giant cell
- poor prognosis
- induced apoptosis
- early stage
- magnetic resonance imaging
- cell cycle arrest
- long non coding rna
- machine learning
- endoplasmic reticulum stress
- computed tomography
- cell death
- squamous cell carcinoma
- rectal cancer
- oxidative stress
- peripheral blood
- rare case
- magnetic resonance
- lymph node
- pi k akt
- ultrasound guided
- locally advanced
- diffusion weighted imaging