Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors.
Urszula RadzikowskaMei DingGe TanDamir ZhakparovYaqi PengPaulina WawrzyniakMing WangShuo LiHideaki MoritaCan AltunbulakliMatthias ReigerAvidan U NeumannNonhlanhla LunjaniClaudia Traidl-HoffmanKari Christine NadeauCorina M BersetMübeccel AkdisMilena SokolowskaPublished in: Allergy (2020)
Our data suggest different receptor repertoire potentially involved in the SARS-CoV-2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID-19 morbidity and severity patterns.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- insulin resistance
- coronavirus disease
- chronic obstructive pulmonary disease
- risk factors
- metabolic syndrome
- weight loss
- lung function
- high fat diet induced
- type diabetes
- weight gain
- mental health
- healthcare
- blood pressure
- public health
- poor prognosis
- gene expression
- electronic health record
- angiotensin ii
- adipose tissue
- smoking cessation
- binding protein
- angiotensin converting enzyme
- big data
- skeletal muscle
- air pollution
- health information
- physical activity
- risk assessment
- body mass index
- human health
- social media
- high throughput sequencing