Changes in Drug Utilization After Publication of Clinical Trials and Drug-Related Scandals in Japan: An Interrupted Time Series Analysis, 2005-2017.

Shingo Fukuma Tatsuyoshi IkenoueYukari YamadaYoshiyuki SaitoJoseph GreenTakeo NakayamaShunichi Fukuhara

Published in: Journal of epidemiology (2020)

The scandals were associated with decrease in the use of first-generation ARBs, and that decrease was greater than the increase associated with the publication of "successful" clinical trials, making the net effect not zero but negative.

Keyphrases

clinical trial
phase ii
drug induced
adverse drug
open label
randomized controlled trial
double blind
emergency department
study protocol
placebo controlled