ApoE Modifier Alleles for Alzheimer's Disease Discovered by Information Theory Dependency Measures: MIST Software Package.
Andrew BanmanNikita A SakhanenkoJames Kunert-GrafDavid J GalasPublished in: Journal of computational biology : a journal of computational molecular cell biology (2022)
Information theory-based measures of variable dependency (previously published) have been implemented into a software package, MIST. The design of the software and its potential uses are described, and a demonstration is presented in the discovery of modifier alleles of the ApoE gene in affecting Alzheimer's disease (AD) by analyzing the UK Biobank dataset. The modifier genes uncovered overlap strongly with genes found to be associated with AD. Others include many known to influence AD. We discuss a range of uses of the dependency calculations using MIST that can uncover additional genetic effects in similar complex datasets, like higher degrees of interaction and phenotypic pleiotropy.
Keyphrases
- cognitive decline
- genome wide
- genome wide identification
- copy number
- mild cognitive impairment
- data analysis
- dna methylation
- small molecule
- health information
- genome wide analysis
- molecular dynamics
- density functional theory
- bioinformatics analysis
- randomized controlled trial
- healthcare
- systematic review
- high throughput
- molecular dynamics simulations
- type diabetes
- skeletal muscle
- rna seq
- monte carlo