Immunophenotype and antitumor activity of cytokine-induced killer cells from patients with hepatocellular carcinoma.
Chan-Keng YangChien-Hao HuangChing-Hsun HuJian-He FangTse-Ching ChenYung-Chang LinYung-Chang LinPublished in: PloS one (2023)
This study revealed that CIK cells from HCC patients possess cytotoxic properties, and express increased levels of effector NK receptors and chemokine molecules and lower levels of suppressive checkpoint receptors. CIK cells can suppress human HCC ex-vivo and in vivo. Future clinical trials of human CIK cell therapy for HCC are warranted.
Keyphrases
- endothelial cells
- clinical trial
- end stage renal disease
- single cell
- high glucose
- induced apoptosis
- ejection fraction
- induced pluripotent stem cells
- newly diagnosed
- chronic kidney disease
- dna damage
- prognostic factors
- stem cells
- cell cycle
- diabetic rats
- randomized controlled trial
- dendritic cells
- cell therapy
- oxidative stress
- cell proliferation
- current status
- immune response
- bone marrow
- phase ii