Associations of apelin, leptin, irisin, ghrelin, insulin, glucose levels, and lipid parameters with physical activity during eight weeks of regular exercise training.

This study demonstrated that after 8 weeks of chronic exercise training, apelin and ghrelin levels increased; in contrast, leptin, irisin, and insulin levels decreased. The decrease in leptin and irisin levels is compatible with the pattern of decrease in the lipid levels as a result of chronic exercise.