Oxygen concentration modulates cellular senescence and autophagy in human trophoblast cells.

Kotomi SenoNao TanikawaHironori TakahashiAkihide OhkuchiHirotada SuzukiShigeki MatsubaraHisataka IwataTakehito KuwayamaKoumei Shirasuna

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)

We conclude that O2 concentration modulates cellular senescence phenotypes regulating autophagy in the human trophoblast cells. Moreover, inhibiting autophagy suppresses cellular senescence, suggesting that autophagy contributes to oxygen stress-induced cellular senescence.

Keyphrases

stress induced
endothelial cells
induced apoptosis
signaling pathway
endoplasmic reticulum stress
cell death
cell cycle arrest
oxidative stress
dna damage
pi k akt
induced pluripotent stem cells
pluripotent stem cells