Oxygen concentration modulates cellular senescence and autophagy in human trophoblast cells.
Kotomi SenoNao TanikawaHironori TakahashiAkihide OhkuchiHirotada SuzukiShigeki MatsubaraHisataka IwataTakehito KuwayamaKoumei ShirasunaPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
We conclude that O2 concentration modulates cellular senescence phenotypes regulating autophagy in the human trophoblast cells. Moreover, inhibiting autophagy suppresses cellular senescence, suggesting that autophagy contributes to oxygen stress-induced cellular senescence.