TLR7-let-7 Signaling Contributes to Ethanol-Induced Hepatic Inflammatory Response in Mice and in Alcoholic Hepatitis.

Veronica L MasseyLiya QinJoaquin CabezasJuan CaballeriaPau Sancho-BruRamon BatallerFulton T Crews

Published in: Alcoholism, clinical and experimental research (2018)

These studies suggest that increased TLR7 signaling caused by increased expression of TLR7 and its endogenous ligand let-7b may contribute to the enhanced inflammatory response associated with AH.

Keyphrases

inflammatory response
toll like receptor
lipopolysaccharide induced
lps induced
poor prognosis
liver injury
drug induced
high glucose
nuclear factor
immune response
metabolic syndrome
high fat diet induced
endothelial cells
adipose tissue
long non coding rna