Genes uniquely expressed in human growth plate chondrocytes uncover a distinct regulatory network.
Bing LiKarthika BalasubramanianDeborah KrakowDaniel H CohnPublished in: BMC genomics (2017)
Our findings revealed a complex gene regulatory network controlling skeletal development whereby transcription factors, enhancers and lncRNAs participate in chondrogenesis by transcriptional regulation of key genes. Additionally, the cartilage-selective genes represent candidate genes for unsolved human skeletal disorders.