A pilot study: Nano-hydroxyapatite-PEG/PLA containing low dose rhBMP2 stimulates proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells.

Eda Çiftci Dede Merve GizerFeza KorkusuzZeynep BalHiroyuki IshiguroHideki YoshikawaTakashi Kaito Petek Korkusuz

Published in: JOR spine (2023)

rhBMP2 + nHAp-PEG/PLA composites stimulate hBMMSC proliferation and differentiation. The nHAp-PEG/PLA composite with low dose of rhBMP2 may enhance bone formation in future clinical PLSF applications.

Keyphrases

low dose
bone marrow
drug delivery
recombinant human
high dose
signaling pathway
endothelial cells
mesenchymal stem cells
induced pluripotent stem cells
pluripotent stem cells
reduced graphene oxide
gold nanoparticles
aqueous solution